The cell according to claim 6 or 7, wherein the double-stranded RNA comprising a RNA selected from the group consisting of (a) and (b) and its complementary RNA is introduced into or expressed in the cell to thereby decrease the amount of mRNA of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body: (a) an RNA comprising the nucleotide sequence represented by SEQ ID NO:33 (b) an RNA which comprises a nucleotide sequence in which one or a few nucleotide are deleted or added in the nucleotide sequence represented by SEQ ID NO:33 and has substantially the same RNAi activity as the nucleotide sequence represented by SEQ ID NO:33.Д©. The cell according to claim 6, wherein a double-stranded RNA comprising an RNA and its comlementary RNA is introduced into or expressed in the cell, said RNA comprised in the double-stranded RNA being selected from the group consisting of the following (a) to (d) and being capable of decreasing the amount of mRNA of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body: (a) an RNA corresponding to a DNA comprising a nucleotide sequence of continuous 10 to 30 nucleotides in the nucleotide sequence represented by SEQ ID NO:1 (b) an RNA corresponding to a DNA comprising a nucleotide sequence of continuous 10 to 30 nucleotides in the nucleotide sequence represented by SEQ ID NO:3 (c) an RNA corresponding to a DNA comprising a nucleotide sequence of continuous 10 to 30 nucleotides in the nucleotide sequence represented by SEQ ID NO:29 (d) an RNA corresponding to a DNA comprising a nucleotide sequence of continuous 10 to 30 nucleotides in the nucleotide sequence represented by SEQ ID NO:30.ДЁ. The cell according to claim 3, wherein the technique for suprressing transcription and/or translation of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body is an RNAi (RNA interference) method.Д§.

The cell according to claim 4, wherein the N-terminal deletion mutant of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body is an N-terminal deletion mutant in which 30 amino acids at the N-terminal of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body are deleted.Д¦. The cell according to claim 3, wherein the dominant negative mutant of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body is an N-terminal deletion mutant of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body.ДҐ.

The cell according to any one of claims 2 to 5, wherein the genetic engineering technique is selected from the group consisting of (a) to (d): (a) a gene disruption technique which comprises targeting a gene encoding a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body (b) a technique for introducing a dominant negative mutant of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body (c) a technique for introducing mutation into a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body (d) a technique for suprressing transcription and/or translation of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body.Д¤.

The cell according to claim 1, wherein the activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body is decreased or deleted by a genetic engineering technique.ДЈ. A cell in which the activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body is more decreased or deleted than its parent cell.Дў.

Properties of parallel lines gsp5